Relationship between αENaC gene G (3091)A polymorphism and essential hypertension in the Xinjiang Kazakans population

AIM: To investigate the relationship between αENaC gene G(3091)A polymorphism and essential hypertension in Xinjiang Kazakans population. METHODS: Two hundred fifty nine essential hypertensive patients (EH groups) with SBP ≥140 mmHg and/or DBP ≥90 mmHg and 266 normotensive subjects (control groups) with BP <140/90 mmHg were selected from a Xinjiang Kazakans population. Genotypes of αENaC gene G(3091)A polymorphism were detected by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique, and its distribution and relationship to hypertension were investigated. RESULTS: In the studied population, frequencies of genotypes AA, AG and GG were 0.196, 0.520 and 0.284, respectively, and frequencies of alleles A and G were 0.455 and 0.545, respectively. Genotypes and allele frequencies were in Hardy-Weinberg equilibrium (χ2＝1.21, P＝0.27). The distributed frequencies of AA, AG and GG were 0.197, 0.521 and 0.282 in hypertensive patients and 0.195, 0.519 and 0.286 in controls, respectively. The distributed frequencies of A and G alleles were 0.456 and 0.544 in hypertensive patients and 0.454 and 0.546 in controls, respectively. No significant differences in genotype and allele distributions were found between EH groups and control groups. No significant differences in blood pressure were found among the three genotypes. By analyzing the data stratified according to gender and BMI, no significant difference in the distribution of genotype frequencies were found between EH group and control group. Using multiple logistic analyses, the genotype of the G(3091)A polymorphism was excluded as an independent variable. CONCLUSION: Polymorphism of αENaC gene G(3091)A existed in the Xinjiang Kazakans population and the αENaC gene G(3091)A polymorphism may not be associated with essential hypertension in Kazakans population.