Effect of tangxintong particles on NF-κB expression in streptozotocin hyperlipemic diabetic rats

AIM: To observe the effect of tangxintong particles on NF-κB expression in streptozotocin (STZ) hyperlipemic diabetic rats. METHODS: Hyperlipemic diabetic rats were induced by IP injection of STZ and hyperlipemic diet. Distribution of NF-κB in myocardial cells was measured by immunohistochemistry, and the effect of tangxintong particles on the expression of NF-κB was observed. RESULTS: Tangxintong particles dose-dependently inhibited overexpression of NF-κB in myocardial cells of hyperlipemic diabetic rats. CONCLUSION: Tangxintong particles have some protective effect on myocardium of diabetic rats, which may be related to the inhibition of NF-κB expression.