Effects of salusin-β on heart ischemia-reperfusion injury

AIM: To investigate whether salusin-β, a new regulatory peptide relevant to the cardiovascular system, can alleviate heart ischemia-reperfusion injury. METHODS: The effects of salusin-β on heart rate (HR), coronary flow (CF) and heart function (LVSP, LVEDP and ±dp/dt) were observed in isolated rat hearts after ischemia-reperfusion. RESULTS: Treatment with 10-8 mol/L salusin-β significantly improved the post-ischemic CF, LVDP, LVEDP and ±dp/dt compared with those of the untreated hearts. The recovery of CF, LVDP, +dp/dt and dp/dt after reperfusion for 30 min was, respectively, (52±5)%, (79±8)%, (70±8)% and (69±10)% vs. (45±6)%, (68±10)%, (58±11)% and (57±8)% in control group (P<0.01, n=8). In addition, in the presence of 10-8 mol/L salusin-β, LVEDP (28.25±7.62)mmHg improved significantly compared with that in control group (52.52±11.27)mmHg. CONCLUSION: These results show that salusin-β alleviates ischemia-reperfusion injury and improves heart function.