Advances of study on involvement of calcium sensing receptor in the formation of hypoxic pulmonary hypertension

The mechanism underlying the formation of hypoxic pulmomary hypertension (HPH) is still unclear at present, more and more research indicated that calcium sensing receptor (CaSR) participated in the occurrence and development of HPH. Increasing evidence suggested that CaSR expressed in the pulmonary artery smooth muscle cells (PASMCs) and CaSR played an important role in the regulation of calcium concentration in the PASMCs, the regulation of pulmonary vascular tensity and the control of PASMC proliferation. Therefore, the study on the role of CaSR in HPH might provide a new direction for clarifying the pathogenesis of HPH. This article reviews the involvement of CaSR in the formation of HPH.