Relationship between vitamin D deficiency and serum NTprobrain natriuretic peptide concentration in patients with hypertension

AIM:To study the relationship between vitamin D deficiency and serum NT-pro-brain natriuretic peptide in hypertensive patients. METHODS: On the basis of the plasma levels of 25(OH)D, hypertensive patients in our hospital from 2009 to 2012 were divided into four groups: control group with 25(OH)D density≥30 ng/ml, group B with 20 ng/ml<25(OH)D density<30 ng/ml, group C with 10 ng/ml<25(OH)D density<20 ng/ml and group D with 25(OH)D density≤10 ng/ml. Serum NT-pro-brain natriuretic peptide concentration was evaluated and the correlation between serum indexes and serum NT-pro-brain natriuretic peptide concentration was analyzed. RESULTS: A total of 150 hypertensive patients aged 30-85 years were included in the study. No significant difference was found in the serum NT-pro-brain natriuretic peptide concentration between groups B and C and control group (95%CI: -38.63-195.92, P>0.05; 95%CI: 84.44-311.25, P>0.05). Serum NT-pro-brain natriuretic peptide concentration in group D was significantly higher than in control group (95%CI: 181.42-409.99, P<0.05) and was significantly higher than in group C. Serum NTprobrain natriuretic peptide concentration in each group markedly increased with the decrease of plasma levels of 25(OH)D. No correlation was found between the serum NTprobrain natriuretic peptide concentration and serum indexes including blood sugar, blood calcium, total cholesterol, triglyceride, homocysteine, creatinine and parathormone. CONCLUSION: Vitamin D deficiency obviously enhances the risk of heart failure in hypertensive patients.