Analysis of serum uric acid and cardiovascular risk factors in elderly patients with essential hypertension

AIM: To study serum uric acid (SUA), blood lipids, insulin resistance, and endogenous creatinine clearance in elderly hypertensive patients. METHODS: Serum uric acid and other clinical data were collected in 78 elderly hypertensive patients (group A), 57 middle-aged hypertensive patients (group B) and 41 elderly normal controls (group C). RESULTS: Hyperuricemia in groups A, B and C was 23, 28 and 2%, respectively. In group A, the BMI, waist-to-hip ratio (WHR), SUA, triglycerides, total cholesterol, systolic blood pressure (SBP), diastolic blood pressure (DBP), Fin and HOMA-IR were higher than in group C, but creatinine clearance (Ccr) and high-density lipoprotein cholesterol were lower than in group C (P<0.05). WHR, Fin, HOMA-IR, Ccr and DBP in group A were lower than in group B (P<0.05). CONCLUSION: The incidence of hyperuricemia is significantly increased in hypertensive patients. The serum uric acid is one of the important markers for clinical analysis in both elderly and middle-aged hypertensive patients.