Effects of low-decibel infrasound on cardiac fibrosis of rats with acute myocardial infarction and underlying mechanism

AIM: To observe the changes of cardiac fibrosis and its underlying mechanism after acute myocardial infarction in rats. METHODS: Thirty male Sprague Dawley rats were randomized to control group, infarction group and infrasound treatment group (10 rats/group). Rats in the infrasound treatment group were treated with infrasound for 7 days, 0.5 h, twice/day. Collagen expression of rat myocardium and contents of NO and Ang-II in rat plasma and rat heart function were observed. RESULTS: Compared with those in the infarction group, the collagen expression of rat myocardium increased in the infrasound treatment group (P<0.01), the contents of NO in rat plasma significantly decreased (P<0.01), the contents of ET-1 in rat plasma significantly increased (P<0.01), and heart function was significantly improved. CONCLUSION: Infrasound treatment significantly assuages the cardiac fibrosis of rats after myocardial infarction, which may be relative with the changes of NO and Ang-II.