Association between endothelial lipase 584C/T gene polymorphism and acute coronary syndrome and lipids

AIM:To explore the potential relationship between EL 584C/T gene polymorphism and ACS or lipid levels. METHODS: EL gene 584C/T genotypes in 324 patients with acute coronary syndrome (ACS) and 299 controls were detected by polymerase chain reaction-restriction fragment length polymorphism analysis. RESULTS: Compared with the levels in controls, levels of HDL, ApoAI and ApoA-I/ApoB were obviously lower in ACS group, but the level of LP(α) was significantly higher. EL gene 584C/T polymorphism was seen in the Chinese Han population of Changzhou region. Frequencies of the CC, CT and TT genotypes were, respectively, 60.2%, 35.8% and 4.0% in the ACS group, and 56.2%, 40.8% and 3.0% in control group. No significant difference was observed in genotype frequencies and allele frequencies between ACS group and control group. Logistic regression analysis showed no significant difference in the relationship between EL gene 584C/T polymorphism and ACS after adjusting for gender, age, current smoking status, hypertension, diabetes mellitus, and hyperlipidemia. No significant difference was found in lipid levels and their ratios between CC genotype and T allele carrier (CT+TT genotypes). CONCLUSION: No significant relationship is found between EL gene 584C/T polymorphism and ACS or lipid levels. EL 584C/T gene polymorphism may not be involved in the pathogenesis of ACS in the Chinese Han population of Changzhou region.