The effects of trimetazidine combined shenmai injection on myocardial injury by disulfiram reaction

AIM To observe the effect of trimetazidine combined with shenmai injection on myocardial injury induced by dithiolamlike. METHODS According to admission orders, 47 patients were divided into two groups: a standard therapy group (n=24) and a trimetazidine combined shenmai injection group (n=23). The standard therapy group accepted routine treatment and the combined therapy group accepted trimetazidine combined shenmai injection based on the conventional treatment. Length of hopitalization, cardiac biomarkers, C-reactive protein levels, electrocardiogram on immedate admission to the hospital and three days after treatment were observed. RESULTS The morbidity rate of myocardial injury by disulfiram reaction was 7.6%. Cardiac biomarkers and C-reactive protein levels were lower, total effective rate were higher ［(87%) vs.(46%)］, length of hopitalization were shorter ［(43±22)h vs.(86±24)h in the combined therapy group than those in the standard therapy group (P<0.05)］. CONCLUSION The effects of trimetazidine combined shenmai injection on myocardial injury by disulfiram reaction were better than that of conventional therapy.