Impact of defibrase on hsCRP and TNF-α in patients with nonST segment elevation myocardial infarction

AIM:To probe the impact of defibrase on hsCRP and TNFα in patients with nonST segment myocardial infarction (NSTEMI). METHODS: Eightysix patients with NSTEMI were randomly divided into two groups: control group and treatment group. Standardized treatment was given to the two groups and defibrase was added in the treatment group. ELISA was used to analyze plasma TNFα level and LaTeX enhanced immune turbidimetry method was employed to detect hsCRP. RESULTS: Both TNFα level and hsCRP level significantly decreased in the treatment group compared with the control group (P<0.05). There was no significant difference in the total efficiency rate between the treatment group and control group, but there was an obvious increasing tendency. CONCLUSION: On the basis of standardized treatment, defibrase decreases the levels of inflammation index (TNF-α and hsCRP) in patients with NSTEMI.