Effect of bisoprolol on left ventricular hypertrophy

AIM: To observe the effect of bisoprolol on left ventricular hypertrophy. METHODS: Forty patients with essential hypertension and left ventricular hypertrophy (LVH) were treated with bisoprolol (2.5-10 mg/day) for 24 weeks. Blood pressure, left ventricle diastolic dimension (LVEDD), interventricular septum thickness (LVST), left ventricle mass index (LVMI), left ventricle posterior wall thickness (LVPWT), procollagen type III (PCIII), insulin-like growth factor-I (IGF-I), and tumor necrosis factor-α (TNF-α) were measured before and after treatment. RESULTS: After bisoprolol treatment, blood pressure and LVMI, LVPWT, LVST and LVEDD levels significantly decreased (P<0.01). In addition, PCIII, IGF-I and TNF-α levels also significantly decreased (P<0.01). CONCLUSION: Bisoprolol lowers hypertension and reverses LVH. The protective mechanism may be related to its ability to reduce IGF-I and TNF-α.