Predictive value of serum proBNP concentration for coronary heart disease

AIM To investigate the association between serum proBNP concentration and the severity of coronary artery lesions and to evaluate the working efficiency of serum proBNP concentration in screening acute coronary syndrome (ACS) and coronary artery stenosis. METHODSOne hundred and sixty-three patients were enrolled in this study. All patients underwent coronary angiography (CAG) and were classified into four groups: non-coronary heart diseas (non-CHD) group (coronary artery stenosis <50%), single-vessel group, double-vessel group and multiple-vessel group (coronary artery stenosis >50%). Also, according to clinical manifestations and diagnoses, the patients were classified into stable angina group (SA group), unstable angina group (UAP group) and acute myocardial infarction group (AMI group). Serum proBNP concentrations were measured and compared between groups. RESULTSThe best cutoff value of proBNP in screening coronary artery stenosis was 94.01 pg/ml. The area under ROC curve was 0.845 and the sensitivity and the specificity were 73.1% and 88.9%. The positive predictive value was 98.2%. The best cutoff value of proBNP in screening ACS was 94.01 pg/ml. The area under ROC curve was 0.947 and the sensitivity and the specificity were 91.3% and 88.9%. The positive predictive value was 97.3%. The combined test of proBNP and CK or CKMB improved the specificity. Serum proBNP concentrations in multiple-vessel group, double-vessel group and single-vessel group were significantly higher than those in control group (P<0.05) and was different between any two groups (P<0.05). The higher the number of stenosed vessels, the higher the serum proBNP concentration. Moreover, proBNP concentration in AMI group was significantly higher than in other groups (P<0.05). proBNP concentration in UA group was higher than in SA group and control group (P<0.05) and proBNP concentration in SA group was markedly higher than in control group (P<0.05). CONCLUSIONSerum proBNP concentration is related to the severity of coronary artery lesions and has high value in screening coronary artery stenosis and ACS patients.