Association between angiotensin II type 1 receptor gene A1166C polymorphism and extent of coronary stenosis in patients with acute myocardial infarction

AIM:To study the relationship between the angiotensin II type 1 receptor (AT1R) gene A1166C polymorphism and the extent of coronary stenosis in patients with acute myocardial infarction (AMI). METHODS: The A1166C polymorphism of 105 primary AMI patients was detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). All patients underwent coronary angiography, and the number of affected coronary vessels (≥50% stenosis) and the coronary Gensini score were determined by the results of coronary angiography. RESULTS: Either the number of affected coronary vessels or the coronary Gensini score in AC+CC genotype carriers was significantly higher than in AA genotype carriers (P<0.05). CONCLUSION: The AT1R gene A1166C polymorphism may be related to the extent of coronary stenosis in AMI patients.