Variance of IL-6, IL-10, and MMP-1 in patients with acute coronary syndrome after percutaneous coronary intervention and the interrelation of cytokines and restenosis

AIM: To detect the variance of IL-6, IL-10, and MMP-1 in patients with acute coronary syndrome (ACS) after percutaneous coronary intervention (PCI) and the interrelation of cytokines and restenosis. METHODS: Serum concentrations of IL-6, IL-10 and MMP-1 were measured in 64 patients with ACS. Pre- and post-PCI was done by enzyme-linked immunosorbent assay (ELISA), and patients were followed-up after 6 months. RESULTS: Serum concentrations of IL-6 and MMP-1 significantly increased after PCI. When comparing the restenosis group to the no-restenosis qroup, they are different both pre- and post-PCI. CONCLUSION: Serum inflammatory levels were augmented by PCI and may predict restenosis.