Suppression of Akt pathway by protein phosphatase PHLPP

As a novel protein phosphatase, PHLPP specifically induces dephosphorylation of protein kinase B (Akt) that inhibits Akt activity. The role of PHLPP in cell physiological regulation has led to increasing attention to this process. The close relationship with the onset of tumors, diabetes and myocardial ischemia/reperfusion injury all highlight the important biological function of PHLPP.