Expression of heat shock protein 47 and its correlation to some factors with chronic heart failure

AIM To investigate the correlation between heat shock protein 47 and some factors in chronic heart failure. METHODS Right atrial tissues were taken from 60 patients undergoing cardiac surgery. Twenty patients were in NYHA I group, 20 patients were in NYHA II group, and 20 patients were in NYHA III group. mRNA amounts of HSP47 were studied by real-time fluorescence quantitative PCR method. RESULTSHS P47mRNA was expressed in patients with chronic heart failure. There was a conspicuous and independent direct correlation between the expression of HSP47 and left ventricular diameter (r=0.785, P<0.05) and there was also an indirect correlation between the expression of HSP47 and EF. There was no correlation between the expression of HSP47 and ages, blood lipids and other factors in chronic heart failure. CONCLUSION In patients with chronic heart failure, heart function declined and expression of HSP47mRNA expression increased. Expression of HSP47 has a positive correlation with left ventricular diameter and a negative correlation with left ventricular ejection fraction.thromboembolism after RFCA.