Effects of atorvastatin on atrial and pulmonary vein electrical activity

AIM To observe the effects of atorvastatin on atrial and pulmonary vein electrical activity. METHODS Fourteen dogs were randomly divided into the control group (n=7) and the atorvastatin group (n=7), and atorvastatin was administered orally (2 mg/kg/day) 4 weeks before operation. The atrial effective refractory period (AERP) and pulmonary vein effective refractory period (AERP) were determined. RESULTS Atorvastatin group had a longer AERP and a longer AERP rate adapting feature. In induced atrial fibrillation, the atorvastin group had a lower rate than the control group. CONCLUSION Atorvastatin effectively improves the atrial electrical activity and reduces the occurrence and recurrence of atrial fibrillation.