Effects of trimetazidine in senile patients with left ventricular diastolic dysfunction

AIM To evaluate the effect of trimetazidine in combination with routine treatment on the improvement in the heart function and hemodynamics in patients with left ventricular diastolic dysfunction. METHODS Ninety-seven senile patients with left ventricular diastolic dysfunction were randomly divided into trimetazidine group (trimetazidine 20 mg three times per day plus routine therapy) and control group (routine therapy alone). The clinical symptoms and signs were observed and the heart function, including LVEF, FS, LVEDD LVRFF and E/A, was measured by echocardiography at the baseline and three months after treatment. RESULTS Trimetazidine group had significant improvements in LVEF, FS, LVEDD, LVRFF, E/A, signs and symptoms of heart failure, and quality of life, compared with those in control group (P<0.01). CONCLUSION Trimetazidine, with no obvious side effects, improves heart function and quality of life in patients with left ventricular diastolic dysfunction.