Effect of benazepril and atorvastatin on left ventricular remodeling after acute myocardial infarction

AIM:To investigate the influence of benazepril and atorvastatin on left ventricular (LV) remodeling after acute myocardial infarction (AMI). METHODS: Seventyfour patients with AMI were randomly assigned to control group and observation group (37 patients in each group). Patients in control group received basic treatment, and benazepril and atorvastatin were added to patients in the observation group. Patients intolerant to benazepril were given telmisartan. Cardiac ultrasound was performed at 3 days and 24 weeks after treatment. RESULTS: Left ventricular endsystolic volume (LVESV) and left ventricular enddiastolic volume (LVEDV) in the observation group significantly decreased, whereas left ventricular ejection fraction (LVEF) and VE/VA increased compared with those in control group. Increase in left ventricular mass index (LVMI) was significantly lower than control group (P<005). CONCLUSION: Benazepril and atorvastatin inhibited ventricular remodeling after AMI, and improvement in heart function is obviously superior to the use of only benazepril.