FHL2 regulation of cardiac potassium ion channels

FHL2 protein consists of four complete and one half LIM domains and belongs to a family that includes LIM domain only. LIM domains are proteininteraction domains and participate in multiple biological functions. Previous studies have shown that FHL2 interacts with a variety of proteins such as receptor proteins, structural proteins, transcription factors, signal transduction proteins and metabolic enzymes. FHL2 also regulates the expression of some genes. Recent studies indicated that FHL2 protein is involved in cardiac potassium ion channel regulation. This review summarizes the structure and expression of FHL2 and the regulation of cardiac potassium ion channels by FHL2.