Expression of cardiac TRPC7 channels increases in streptozotocin-induced diabetic rats

AIM:To investigate the change of cardiac TRPC7 expression in streptozotocin (STZ)-induced type 2 diabetic rats. METHODS: STZ-induced type 2 diabetic rat models were established and the expression of cardiac TRPC7 channels was evaluated by immunofluorescence and Western blot. RESULTS: 1) The impaired heart was found in STZ-induced T2DM rats. 2) The expression of cardiac TRPC7 significantly increased in STZ-induced T2DM rats as compared with that in control rats. CONCLUSION: The present work makes a novel finding that the expression of cardiac TRPC7 channels significantly increased in the impaired hearts of STZ-induced type 2 diabetic rats.