Plasma brain natriuretic peptide in predicting in-stent restenosis

AIM: To study the relationship between brain natriuretic peptide (BNP) and intracoronary in-stent restenosis. METHODS: A total of 317 patients with acute coronary syndrome (ACS) or stable angina pectoris (SAP) successfully treated with percutaneous coronary stent implantation (PCI) were examined with a follow-up coronary angiography. Study subjects were divided into in-stent restenosis (ISR) group and no ISR group. Blood samples for BNP were obtained before PCI, at hospital discharge and during angiographic follow-up. RESULTS: Patients with restenosis had significantly higher plasma BNP levels than their counterparts without restenosis (P<0.05). Multivariate logistic regression analysis revealed that high plasma BNP level was an independent predictor of ISR. CONCLUSION: Plasma BNP level can be used as a predictive factor for restenosis after PCI.