New therapeutic developments for fibrotic disease in diabetic cardiomyopathy

Diabetic cardiomyopathic changes include cardiac hypertrophy,interstitial fibrosis and apoptosis of cardiomyoctes. Hyperglycemia,renin-angiotensin-aldosterone system( RAAS),inflammatory factors and matrix metalloproteinases are believed to be associated with diabetic cardiac fibrosis disease. This article reviews new therapeutic developments for diabetic myocardial fibrosis.