Changes of transmural dispersion of repolarization and connexin 43 in rabbits with heart failure

AIM: To investigate the the changes of transmural dispersion of repolarization(TDR) and connexin 43 in rabbit heart failure.METHODS: Models of adriamycin-induced heart failure were established in rabbits and picardial,mid-and endometrial monophasic action potentials(MAP) in the left ventricular myocardium were recorded with MAP recording technology.Monophasic action potential duration MAPD90 was measured,changes of TDR were analyzed,and distribution changes of gap junction connexin 43(CX43) in the myocardial cells were observed by immunofluorescence.RESULTS: Compared with those in the control group,MAPD90 in the heart failure group was shortened and TDR significantly increased(P<0.05).Immunofluorescence showed differences in CX43 distribution between heart failure group and control group.CONCLUSION: Increased TDR and distribution changes of CX43 in heart failure may be related to occurrence of malignant ventricular arrhythmia.