AIM To investigate the expression of serum high-density lipoprotein in patients with idiopathic inflammatory myopathy (IIM) complicated with interstitial lung disease (ILD) and its possible clinical significance.
METHODS A total of 143 IIM patients, who were initially treated at Tangdu Hospital, Air Force Medical University from August 2018 to May 2024, were divided into IIM without ILD group (57 cases) and IIM-ILD group (86 cases) according to whether they were combined with ILD. Their clinical data were analyzed and clinical characteristics and laboratory indexes of the two groups were compared. Multifactor logistic regression was used to analyze the risk factors of IIM combined with ILD and the predictive value of HDL for IIM-ILD was evaluated by using receiver operator characteristic (ROC) curve.
RESULTS The incidence of age (P<0.01) and skilled worker (P<0.05) in the IIM-ILD group was higher than that in the IIM group without ILD; The serum albumin (ALB) (34 ± 5) vs. (37 ± 5), P<0.01 and high-density lipoprotein (0.9 ± 0.3) vs. (1.2 ± 0.5), P<0.01 levels in the IIM-ILD group were lower than those in the IIM without ILD group. The serum ferritin levels 542 (305, 961) vs. 330 (155, 555), P<0.01, and the positivity rate of anti-Ro-52 antibodies 57% vs. 33%, P<0.05 were higher than those in the IIM without ILD group; The results of logistic regression analysis showed that age, positive anti-Ro-52 antibodies, and skilled workers were independent risk factors for IIM-ILD (all P<0.05), while HDL was an independent protective factor for IIM-ILD (P<0.01); The area under the ROC curve of IIM-ILD determined by HDL is 0.766 (95% CI: 0.684～0.849). When the critical value of high-density lipoprotein is set at 1.06, its diagnostic value is the highest, with a sensitivity of 60.71% and a specificity of 84.88%.
CONCLUSION Serum high-density lipoprotein is an independent protective factor for IIM-ILD.
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