CONG Dong-yao, DAI Chen-guang, PAN Yu-jiao. Correlation between multiple serological indicators and in-hospital mortality in elderly patients with acute myocardial infarction and cardiogenic shock[J]. Chinese Heart Journal, 2025, 37(1): 35-40. DOI: 10.12125/j.chj.202312086
    Citation: CONG Dong-yao, DAI Chen-guang, PAN Yu-jiao. Correlation between multiple serological indicators and in-hospital mortality in elderly patients with acute myocardial infarction and cardiogenic shock[J]. Chinese Heart Journal, 2025, 37(1): 35-40. DOI: 10.12125/j.chj.202312086

    Correlation between multiple serological indicators and in-hospital mortality in elderly patients with acute myocardial infarction and cardiogenic shock

    • AIM To assess the role of multiple serological indicators in the prediction of in-hospital death in patients with acute myocardial infarction (AMI) and cardiogenic shock (CS).
      METHODS Three hundred and twenty-six patients with AMI combined with CS in our hospital from January 2018 to June 2023 were retrospectively included, and they were divided into in-hospital death group (120 cases ) and in-hospital survival group (206 cases) according to whether they died during hospitalization. Multifactorial logistic regression was used to screen the risk factors for in-hospital death in patients with AMI and CS, ROC curves were used to assess the differentiation of serological markers for identifying in-hospital death in patients with AMI and CS, and the results were expressed as AUC.
      RESULTS Compared with the in-hospital live group, the in-hospital death group had higher levels of age (P<0.01), uric acid (P<0.05), fibrinogen (P<0.05), lactate (P<0.01), C-reactive protein (P<0.05), neutrophil lymphocyte ratio (NLR) (P<0.01), stress hyperglycemia ratio (SHR) (P<0.01), and lower levels of left ventricular ejection fraction (P<0.01) and TIMI grade 3 blood flow ratio (P<0.01). Multivariate logistic regression analysis showed that age (OR=1.292, 95% CI: 1.002~1.666, P<0.05), NLR (OR=1.616, 95% CI: 1.185~2.205, P<0.01), lactate (OR=1.401, 95% CI: 1.054~1.862, P<0.05), and SHR (OR=1.480, 95% CI: 1.110~1.973, P<0.01) were independent risk factors for in-hospital mortality in patients with AMI and CS, while TIMI blood flow level 3 was a protective factor (OR=0.528, 95% CI: 0.372~0.749, P<0.01). The ROC curve shows that the AUC of NLR, lactate, and SHR predicting in-hospital mortality in AMI patients with CS is 0.831 (95% CI: 0.784~0.878), 0.719 (95% CI: 0.660~0.777), and 0.670 (95% CI: 0.609~0.730), respectively.
      CONCLUSION NLR, lactate and SHR are all correlated with in-hospital death in patients with AMI with CS and they are of some predictive ability for in-hospital mortality risk, with NLR having the best predictive ability.
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