Association of serum 3-nitrotyrosine level with left ventricular diastolic function in type 2 diabetic patients

  AIM   To investigate the relationship between serum 3-nitrotyrosine levels and left ventricular diastolic function in type 2 diabetic patients.

  METHODS   Basic clinical data, cardiac ultrasound indexes and serum 3-NT level were compared between diabetic group and control group. In the diabetic group, the correlation between each factor and left ventricular diastolic function was analyzed by one-way correlation analysis and multiple linear regression and the association between serum 3-NT level and left ventricular diastolic function was analyzed by multivariate logistic regression.

  RESULTS   ① Compared with the control group, the systolic blood pressure, glycosylated hemoglobin and fasting blood glucose in the diabetes group were higher (P<0.01), and the high-density lipoprotein cholesterol was lower (P<0.05), and the serum 3-NT level was significantly higher (P<0.01). Compared with the control group, the parameters of left ventricular diastolic function in the diabetes group were lower in mitral annular interval e' wave velocity (interval e') (P<0.05), mitral annular lateral wall e' wave velocity (lateral wall e') (P<0.01), average e' value (P<0.01), and E/A ratio (P<0.01), while mitral diastolic peak A and average E/e' ratio were higher (P<0.01). ② In the diabetes group, the serum 3-NT level was negatively correlated with the interval e' (r=−0.324, P<0.01), the lateral wall e' (r=−0.360, P<0.01), and positively correlated with the average E/e' ratio (r=0.565, P<0.01). ③ After adjusting for confounding factors by multivariate logistic regression, serum 3-NT level was a common independent risk factor for the average E/e' ratio (OR=1.034, P<0.01), interval e' (OR=1.026, P<0.05), and lateral wall e' (OR=1.036, P<0.01) in patients with type 2 diabetes.

  CONCLUSION   Serum 3-NT level is independently and positively correlated with the mean E/e' ratio (which reflects left ventricular filling pressure) and was independently and negatively correlated with septal e' and lateral wall e' (which reflect left ventricular reflexivity), and it is an independent risk factor for these indices. Serum 3-NT level may be a predictor of early left ventricular diastolic abnormalities in type 2 diabetic patients, which provides a reference basis for the diagnosis of early left ventricular diastolic abnormalities in 2 diabetic patients.