Relationship between PDCD4 expression and blood pressure variability in patients with acute coronary syndrome

  AIM   To study the expression of programmed cell death factor 4 (PDCD4) in patients with acute coronary syndrome (ACS) and its correlation with blood pressure variability.

  METHODS  A total of ACS 270 patients treated in our hospital from January 2019 to January 2021 were selected for this study. According to Gensini score, the 270 patients were divided into mild lesion group (0～30 points, 95 cases), moderate lesion group (31～60 points, 102 cases) and severe lesion group (> 60 points, 73 cases). Their blood pressure was monitored for 24 hours continuously, and 24h standard deviation of mean systolic blood pressure (24 h mSBP-SD), 24 h standard deviation of mean diastolic blood pressure (24 h mDBP-SD), standard deviation of mean systolic blood pressure daytime (d mSBP-SD), standard deviation of mean diastolic blood pressure daytime (d mDBP-SD), standard deviation of mean systolic blood pressure at night (n mSBP-SD) and standard deviation of mean diastolic blood pressure at night (n mDBP-SD) were recorded. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of PDCD4 mRNA in CD4+T cells, Western blotting was used to detect the expression level of PDCD4 protein in CD4+T cells and Pearson method was used to analyze the correlation between PDCD4 mRNA and protein expression and blood pressure variability in ACS patients.

  RESULTS   There was no significant difference between the three groups. In terms of blood pressure variability, the values of 24 h MSBP SD, 24 h mdbp SD, D MSBP SD, D mdbp SD, n MSBP SD and N mdbp SD were significantly increased in moderate lesion group, severe lesion group and mild lesion group (all P<0.01). In terms of molecular biological data such as the expression of PDCD4 mRNA and protein on CD4 + T cells in the three groups, the expression levels of PDCD4 mRNA and protein on CD4 + T cells in patients with moderate and severe lesions were significantly higher than those in patients with mild lesions and patients with severe and moderate lesions (all P<0.01). Pearson analysis showed that the expression levels of PDCD4 mRNA and protein in CD4 + T cells of ACS patients were positively correlated with 24 h MSBP SD, 24 h mdbp SD, D MSBP SD, D mdbp SD, n MSBP SD and N mdbp SD (all P<0.01).

  CONCLUSION   PDCD4 is related to blood pressure variability in patients with ACS and could be used to assess the severity of patients’ condition.