Research progress of IL-35 in cardiovascular diseases

Cardiovascular disease is a common disease that threatens the health of human and is also one of the main causes of death. Cytokines play an important role in the pathogenesis of cardiovascular diseases. As a member of the interleukin-12 (IL-12) family, IL-35 is an inhibitory cytokine produced mainly by regulatory T cells. Recent studies have shown that IL-35 is involved in the development of cardiovascular diseases. This paper reviews the structure, signaling pathway and biological function of IL-35 and summarizes the research progress of the regulatory role and mechanism of IL-35 in the pathogenesis of cardiovascular diseases, aiming to provide new ideas and directions for the prevention and treatment of cardiovascular diseases.