AIM To investigate the expression and clinical significance of long non coding RNA SNHG5 (lncRNA SNHG5) in peripheral blood of patients with coronary atherosclerotic heart disease (CAHD).
METHODS The clinical data of subjects were collected. The expression of lncRNA SNHG5 in peripheral blood of subjects in control group (n = 82) and CAHD group (n = 78) was measured by reverse transcription polymerase chain reaction (qRT-PCR). The independent risk factors affecting CAHD were explored by univariate logistic regression analysis. The diagnostic value of lncrna snhg5 in CAHD was analyzed by receiver operating characteristic (ROC) curve.
RESULTS Compared with the control group, the expression level of lncRNA SNHG5 in peripheral blood of subjects in CAHD group decreased significantly (P<0.05). The expression level of lncRNA SNHG5 in peripheral blood of patients with cardiac function grade I-IV CAHD gradually decreased, the difference between grades was P<0.05, and the difference between grades was P<0.01. Hypertension, hyperlipidemia and lncRNA SNHG5 expression were independent risk factors for CAHD. The area under ROC curve of lncRNA SNHG5 in the diagnosis of CAHD was 0.872, the sensitivity was 78.2% and the specificity was 97.60%.
CONCLUSION lncRNA SNHG5 may be a potential serological biomarker for the diagnosis of CAHD.
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