AIM To observe the therapeutic effect and possible mechanism of Shenqi Xuefu Zhuyu Decoction combined with conventional therapy in the treatment of diabetic cardiomyopathy.
METHODS One hundred cases of diabetic cardiomyopathy with deficiency of Qi and Yin and blood stasis were divided randomly into treatment group and control group, 50 cases in each group. The control group was treated with standardized treatment of Western medicine and the treatment group was combined with Shenqi Xuefu Zhuyu Decoction on the basis of the control group. Both groups were treated continuously for 2 months. Clinical total effective rate, detecting cardiac function indicators before and after the treatment LVESD, LVEDD, LVEF, 6MWT, oxidative stress indexes T-AOC, SOD, GSH-PX and inflammation indicators IL-6, TNF-α, NLRP3, ASC were compared between the two groups.
RESULTS Compared with those before treatment, the cardiac function indexes LVESD, LVEDD, LVEF and 6MWT were significantly improved in both groups (P<0.05), serum SOD, T-AOC and GSH-PX were significantly increased (P<0.05) and inflammation indicators in serum IL-6, TNF-α, NLRP3 and ASC were significantly decreased after treatment (P<0.05). Compared with those in control group, the total effective rate of the treatment group (88.0%) was significantly higher than that in the control group (P<0.05), cardiac function indexes in the treatment were significantly better improved (P<0.05), the serum SOD, T-AOC and GSH-PX in the treatment group were significantly higher (P<0.05) and the serum inflammation indicators were significantly lower (P<0.05).
CONCLUSION Shenqi Xuefu Zhuyu Decoction is effective in the treatment of diabetic cardiomyopathy and significantly improves the cardiac functions. It plays a significant role in anti-oxidative stress and anti-inflammation and effectively inhibits the development of diabetic cardiomyopathy.
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