• 中国科技核心期刊
  • 中文科技期刊数据库刊源
  • 中国科技论文统计源期刊
  • 美国化学文摘社《化学文摘》刊源
Volume 34 Issue 3
May  2022
Turn off MathJax
Article Contents
Yi-hua LI, Ya LI, Zhen-yu CAI, Dong-jing ZHOU. Predictive value of coronary artery calcification score and cardiac troponin I for poor outcomes in patients with heart failure with preserved ejection fraction[J]. Chinese Heart Journal, 2022, 34(3): 275-279. doi: 10.12125/j.chj.202107028
Citation: Yi-hua LI, Ya LI, Zhen-yu CAI, Dong-jing ZHOU. Predictive value of coronary artery calcification score and cardiac troponin I for poor outcomes in patients with heart failure with preserved ejection fraction[J]. Chinese Heart Journal, 2022, 34(3): 275-279. doi: 10.12125/j.chj.202107028

Predictive value of coronary artery calcification score and cardiac troponin I for poor outcomes in patients with heart failure with preserved ejection fraction

doi: 10.12125/j.chj.202107028
  • Received Date: 2021-07-13
  • Accepted Date: 2021-11-03
  • Rev Recd Date: 2021-10-16
  • Publish Date: 2022-05-26
  •   AIM  To investigate the predictive value of high sensitive cardiac troponin I (Hs-cTnI) and coronary artery calcification score (CACS) using spiral CT in patients with heart failure with preserved ejection fraction (HFpEF).   METHODS  We retrospectively analyzed HFpEF patients in our hospital from January 2017 to December 2019. The occurrence of adverse events was recorded via telephone follow-up. A total of 235 HFpEF patients were collected, 16 were lost to follow-up, and 219 were included. The follow-up time was (40±21) months. A total of 80 all-cause deaths occurred and 56 were cardiac death. Single-factor analysis and multi-factor analysis were carried out through COX regression model, and indicators that had predictive value for HFpEF death were obtained. Finally, receiver operating characteristic curve (ROC) was used to analyze the predictive value of CACS and Hs-cTnI for death of HFpEF patients.   RESULTS  CACS classification, Hs-cTnI and brain natriuretic peptide (BNP) levels were positively correlated (r=0.3081, P<0.05 and r=0.7081, P<0.05); Multivariate COX regression showed that BNP, CACS and Hs-cTnI were independent predictors for the occurrence of all-cause death and cardiac death in patients with HFpEF patients (P<0.05). ROC analysis showed that the AUC value, sensitivity and specificity of combining CACS and Hs-cTnI for adverse events in HFpEF patients were higher than those of one individual predictor.   CONCLUSION  Hs-cTnI and CACS are good predictors for all-cause death and cardiovascular death in patients with HFpEF, and Hs-cTnI combined with CaCS has higher predictive value.

     

  • loading
  • [1]
    Upadhya B, Kitzman DW. Heart failure with preserved ejection fraction: new approaches to diagnosis and management[J]. Clin Cardiol, 2020, 43(2): 145 – 155. doi: 10.1002/clc.23321
    [2]
    Ezekowitz JA, O'Meara E, McDonald MA, et al. 2017 Comprehensive update of the canadian cardiovascular society guidelines for the management of heart failure[J]. Can J Cardiol, 2017, 33(11): 1342 – 1433. doi: 10.1016/j.cjca.2017.08.022
    [3]
    Shen YW, Wu YJ, Hung YC, et al. Natural course of coronary artery calcium progression in Asian population with an initial score of zero[J]. BMC Cardiovasc Disord, 2020, 20(1): 212. doi: 10.1186/s12872-020-01498-x
    [4]
    Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American college of cardiology/American heart association task force on clinical practice guidelines[J]. Circulation, 2019, 140(11): e596 – e646. doi: 10.1161/CIR.0000000000000678
    [5]
    Detrano R, Guerci AD, Carr JJ, et al. Coronary calcium as a predictor of coronary events in four racial or ethnic groups[J]. N Engl J Med, 2008, 358(13): 1336 – 1345. doi: 10.1056/NEJMoa072100
    [6]
    中华医学会心血管病学分会心力衰竭学组, 中国医师协会心力衰竭专业委员会, 中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2018[J]. 中华心血管病杂志, 2018, 46(10): 760 – 789. doi: 10.3760/cma.j.issn.0253-3758.2018.10.004
    [7]
    Pandey A, Golwala H, Sheng S, et al. Factors associated with and prognostic implications of cardiac troponin elevation in decompensated heart failure with preserved ejection fraction: findings from the American Heart Association get with the guidelines-heart failure program[J]. JAMA Cardiol, 2017, 2(2): 136 – 145. doi: 10.1001/jamacardio.2016.4726
    [8]
    Perna ER, Aspromonte N, Cimbaro Canella JP, et al. Minor myocardial damage is a prevalent condition in patients with acute heart failure syndromes and preserved systolic function with long-term prognostic implications: a report from the CIAST-HF (Collaborative Italo-Argentinean Study on cardiac Troponin T in Heart Failure) study[J]. J Card Fail, 2012, 18(11): 822 – 830. doi: 10.1016/j.cardfail.2012.10.008
    [9]
    Gohar A, Chong JPC, Liew OW, et al. The prognostic value of highly sensitive cardiac troponin assays for adverse events in men and women with stable heart failure and a preserved vs. reduced ejection fraction[J]. Eur J Heart Fail, 2017, 19(12): 1638 – 1647. doi: 10.1002/ejhf.911
    [10]
    Sanders-van Wijk S, van Empel V, Davarzani N, et al. Circulating biomarkers of distinct pathophysiological pathways in heart failure with preserved vs. reduced left ventricular ejection fraction[J]. Eur J Heart Fail, 2015, 17(10): 1006 – 1014. doi: 10.1002/ejhf.414
    [11]
    Logeart D, Beyne P, Cusson C, et al. Evidence of cardiac myolysis in severe nonischemic heart failure and the potential role of increased wall strain[J]. Am Heart J, 2001, 141(2): 247 – 253. doi: 10.1067/mhj.2001.111767
    [12]
    Myhre PL, O'Meara E, Claggett BL, et al. Cardiac troponin I and risk of cardiac events in patients with heart failure and preserved ejection fraction[J]. Circ Heart Fail, 2018, 11(11): e005312. doi: 10.1161/CIRCHEARTFAILURE.118.005312
    [13]
    Obokata M, Reddy YNV, Melenovsky V, et al. Myocardial injury and cardiac reserve in patients with heart failure and preserved ejection fraction[J]. J Am Coll Cardiol, 2018, 72(1): 29 – 40. doi: 10.1016/j.jacc.2018.04.039
    [14]
    Peix A, Batista E, Cabrera LO, et al. Gated-SPECT myocardial perfusion imaging and coronary calcium score for evaluation of patients with acute chest pain and a normal or nondiagnostic electrocardiogram[J]. Coron Artery Dis, 2012, 23(7): 438 – 444. doi: 10.1097/MCA.0b013e3283576a13
    [15]
    Shah S, Bellam N, Leipsic J, et al. Prognostic significance of calcified plaque among symptomatic patients with nonobstructive coronary artery disease[J]. J Nucl Cardiol, 2014, 21(3): 453 – 466. doi: 10.1007/s12350-014-9865-9
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(2)  / Tables(2)

    Article views (92) PDF downloads(20) Cited by()
    Proportional views

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return