• 中国科技核心期刊
  • 中文科技期刊数据库刊源
  • 中国科技论文统计源期刊
  • 美国化学文摘社《化学文摘》刊源
Volume 34 Issue 3
May  2022
Turn off MathJax
Article Contents
Zi-yong JIA, Gui-xin HE, Ting XIAO, Yu-fei FENG, Juan WEI, Zhen-le HUANG, Wei-bin QIN. Influence of intestinal tract on coronary heart disease based on theory of heart and spleen and progress in application of traditional Chinese medicine[J]. Chinese Heart Journal, 2022, 34(3): 356-361. doi: 10.12125/j.chj.202106004
Citation: Zi-yong JIA, Gui-xin HE, Ting XIAO, Yu-fei FENG, Juan WEI, Zhen-le HUANG, Wei-bin QIN. Influence of intestinal tract on coronary heart disease based on theory of heart and spleen and progress in application of traditional Chinese medicine[J]. Chinese Heart Journal, 2022, 34(3): 356-361. doi: 10.12125/j.chj.202106004

Influence of intestinal tract on coronary heart disease based on theory of heart and spleen and progress in application of traditional Chinese medicine

doi: 10.12125/j.chj.202106004
  • Received Date: 2021-06-01
  • Accepted Date: 2021-12-27
  • Rev Recd Date: 2021-12-08
  • Publish Date: 2022-05-26
  • Coronary heart disease (CHD) is a global disease with high mortality that affects human life and health. At present, percutaneous coronary intervention (PCI) is a common method for the treatment of CHD in China. But the exploration of the pathogenesis of coronary heart disease and the effective prevention and treatment of CHD has remained a hot research topic in clinical research. In recent years, a large number of studies have shown the correlation between intestinal microecology and coronary heart disease, and the theory of “heart and spleen correlation” in Chinese medicine coincides with modern research results. The relationship between intestinal microecology and coronary heart disease has become a breakthrough in the prevention and treatment of coronary heart disease and the Chinese medicine based on the theory of the heart and spleen may play an important role in it. Based on this theory, this paper aims to explore the relationship between intestinal flora and coronary heart disease, the influence of traditional Chinese medicine on intestinal microecology and the possible intervention methods for coronary heart disease.

     

  • loading
  • [1]
    Kazemian N, Mahmoudi M, Halperin F, et al. Gut microbiota and cardiovascular disease: opportunities and challenges[J]. Microbiome, 2020, 8(1): 36. doi: 10.1186/s40168-020-00821-0
    [2]
    冯文林, 伍海涛. 基于《黄帝内经》“甘入脾”理论指导下健脾中药的多糖成分调控IBS-D肠道菌群的机制研究[J]. 辽宁中医杂志, 2019, 46(1): 127 – 129. doi: 10.13192/j.issn.1000-1719.2019.01.042
    [3]
    Rowland I, Gibson G, Heinken A, et al. Gut microbiota functions: metabolism of nutrients and other food components[J]. Eur J Nutr, 2018, 57(1): 1 – 24. doi: 10.1007/s00394-017-1445-8
    [4]
    杨志华, 邓柳颐, 李冬梅, 等. 中药复方对肠道微生态调节作用的研究[J]. 西部中医药, 2020, 33(9): 166 – 168. doi: 10.12174/j.issn.1004-6852.2020.09.42
    [5]
    Zheng D, Liwinski T, Elinav E. Interaction between microbiota and immunity in health and disease[J]. Cell Res, 2020, 30(6): 492 – 506. doi: 10.1038/s41422-020-0332-7
    [6]
    刘绪银, 路志正. 国医大师路志正教授从脾胃论治胸痹(冠心病)[J]. 湖南中医药大学学报, 2015, 35(7): 1 – 4. doi: 10.3969/j.issn.1674-070X.2015.07.001
    [7]
    张翠萍, 王 磊. 肠道菌群——心血管疾病中医药调节的新靶点[J]. 中西医结合心脑血管病杂志, 2018, 16(22): 3379 – 3382. doi: 10.12102/j.issn.1672-1349.2018.22.046
    [8]
    熊 鑫, 张军平, 朱亚萍, 等. 阮士怡基于“正气存内, 邪不可干”理念辨治冠心病的经验初探[J]. 辽宁中医杂志, 2019, 46(11): 2278 – 2280. doi: 10.13192/j.issn.1000-1719.2019.11.009.
    [9]
    王士超, 吴 伟, 刘 芳, 等. 国医大师邓铁涛教授治疗心血管病学术思想和冠心病治疗经验初探[J]. 中西医结合心脑血管病杂志, 2016, 14(10): 1167 – 1170. doi: 10.3969/j.issn.1672-1349.2016.10.039
    [10]
    王 慧, 孔令信, 李正光, 等. 动脉粥样硬化从脾论治[J]. 中医学报, 2021, 36(7): 1371 – 1374. doi: 10.16368/j.issn.1674-8999.2021.07.288
    [11]
    Jia Q, Li H, Zhou H, et al. Role and effective therapeutic target of gut microbiota in heart failure[J]. Cardiovasc Ther, 2019, 2019: 5164298. doi: 10.1155/2019/5164298
    [12]
    Ding L, Chang M, Guo Y, et al. Trimethylamine-n-oxide (TMAO)-induced atherosclerosis is associated with bile acid metabolism[J]. Lipids Health Dis, 2018, 17(1): 286. doi: 10.1186/s12944-018-0939-6
    [13]
    Yang S, Li X, Yang F, et al. Gut microbiota-dependent marker tmao in promoting cardiovascular disease: inflammation mechanism, clinical prognostic, and potential as a therapeutic target[J]. Front Pharmacol, 2019, 10: 1360. doi: 10.3389/fphar.2019.01360
    [14]
    Zhu W, Gregory JC, Org E, et al. Gut microbial metabolite tmao enhances platelet hyperreactivity and thrombosis risk[J]. Cell, 2016, 165(1): 111 – 124. doi: 10.1016/j.cell.2016.02.011
    [15]
    Naghipour S, Cox AJ, Peart JN, et al. Trimethylamine n-oxide: heart of the microbiota-cvd nexus?[J]. Nutr Res Rev, 2021, 34(1): 125 – 146. doi: 10.1017/S0954422420000177
    [16]
    Zununi Vahed S, Barzegari A, Zuluaga M, et al. Myocardial infarction and gut microbiota: an incidental connection[J]. Pharmacol Res, 2018, 129: 308 – 317. doi: 10.1016/j.phrs.2017.11.008
    [17]
    王 波, 陈 翔, 史承勇. 益生菌对稳定性冠心病患者血清TMAO水平的影响及与血清炎性因子水平的相关性[J]. 中国微生态学杂志, 2019, 31(5): 556 – 559,563. doi: 10.13381/j.cnki.cjm.201905012
    [18]
    Luo M, Yan D, Sun Q, et al. Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF-kB/NLRP3 pathway[J]. J Cell Biochem, 2020, 121(4): 2994 – 3004. doi: 10.1002/jcb.29556
    [19]
    Silveira-Nunes G, Durso DF, Jr LRAO, et al. Hypertension is associated with intestinal microbiota dysbiosis and inflammation in a brazilian population[J]. Front Pharmacol, 2020, 11: 258. doi: 10.3389/fphar.2020.00258
    [20]
    Chang Y, Chen Y, Zhou Q, et al. Short-chain fatty acids accompanying changes in the gut microbiome contribute to the development of hypertension in patients with preeclampsia[J]. Clin Sci (Lond), 2020, 134(2): 289 – 302. doi: 10.1042/CS20191253
    [21]
    Zhou C, Li L, Li T, et al. SCFAs induce autophagy in intestinal epithelial cells and relieve colitis by stabilizing HIF-1α[J]. J Mol Med (Berl), 2020, 98(8): 1189 – 1202. doi: 10.1007/s00109-020-01947-2
    [22]
    Aguilar EC, Santos LC, Leonel AJ, et al. Oral butyrate reduces oxidative stress in atherosclerotic lesion sites by a mechanism involving NADPH oxidase down-regulation in endothelial cells[J]. J Nutr Biochem, 2016, 34: 99 – 105. doi: 10.1016/j.jnutbio.2016.05.002
    [23]
    Vasquez EC, Pereira TMC, Peotta VA, et al. Probiotics as beneficial dietary supplements to prevent and treat cardiovascular diseases: uncovering their impact on oxidative stress[J]. Oxid Med Cell Longev, 2019, 2019: 3086270. doi: 10.1155/2019/3086270
    [24]
    Ashaolu TJ. Immune boosting functional foods and their mechanisms: a critical evaluation of probiotics and prebiotics[J]. Biomed Pharmacother, 2020, 130: 110625. doi: 10.1016/j.biopha.2020.110625
    [25]
    Tang TWH, Chen HC, Chen CY, et al. Loss of gut microbiota alters immune system composition and cripples postinfarction cardiac repair[J]. Circulation, 2019, 139(5): 647 – 659. doi: 10.1161/CIRCULATIONAHA.118.035235
    [26]
    Li S, Qi Y, Chen L, et al. Effects of panax ginseng polysaccharides on the gut microbiota in mice with antibiotic-associated diarrhea[J]. Int J Biol Macromol, 2019, 124: 931 – 937. doi: 10.1016/j.ijbiomac.2018.11.271
    [27]
    Kim DH. Gut microbiota-mediated pharmacokinetics of ginseng saponins[J]. J Ginseng Res, 2018, 42(3): 255 – 263. doi: 10.1016/j.jgr.2017.04.011
    [28]
    陈绮映, 林 超, 杨荣丰, 等. 人参皂苷Rh1对TMAO诱导的HUVECs凋亡的保护作用的研究[J]. 广州医科大学学报, 2019, 47(3): 1 – 4. doi: 10.3969/j.issn.2095-9664.2019.03.01
    [29]
    Sun SS, Wang K, Ma K, et al. An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota[J]. Chin J Nat Med, 2019, 17(1): 3 – 14. doi: 10.1016/S1875-5364(19)30003-2
    [30]
    石振国, 苏 锦, 任永乐, 等. 茯苓多糖对急性胰腺炎大鼠肠道屏障功能损伤和炎性反应的作用[J]. 海南医学, 2017, 28(3): 356 – 359. doi: 10.3969/j.issn.1003-6350.2017.03.004
    [31]
    孙晓雨, 崔子寅, 张明亮, 等. 枸杞多糖和茯苓多糖对免疫抑制小鼠免疫增强及对肠道黏膜的免疫调节作用[J]. 中国兽医学报, 2015, 35(3): 450 – 455. doi: 10.16303/j.cnki.1005-4545.2015.03.031
    [32]
    Feng W, Liu J, Tan Y, et al. Polysaccharides from atractylodes macrocephala koidz. ameliorate ulcerative colitis via extensive modification of gut microbiota and host metabolism[J]. Food Res Int, 2020, 138(Pt B): 109777. doi: 10.1016/j.foodres.2020.109777
    [33]
    黄文武, 彭 颖, 王梦月, 等. 四君子汤及其单味药水煎液对脾虚大鼠肠道菌群的调节作用[J]. 中国实验方剂学杂志, 2019, 25(11): 8 – 15. doi: 10.13422/j.cnki.syfjx.20190847
    [34]
    Xu JH, Liu XZ, Pan W, et al. Berberine protects against diet-induced obesity through regulating metabolic endotoxemia and gut hormone levels[J]. Mol Med Rep, 2017, 15(5): 2765 – 2787. doi: 10.3892/mmr.2017.6321
    [35]
    文永均, 黄 璜, 马中刚, 等. 黄连生物碱复合物及其单体通过调节肠道菌群改善小鼠肥胖病症的研究[J]. 食品与发酵科技, 2020, 56(5): 7 – 14. doi: 10.3969/j.issn.1674-506X.2020.05.002
    [36]
    史亚非. 黄连素对ApoE受体基因敲除小鼠肠道菌群结构及动脉粥样硬化的影响[D]. 江苏: 南京医科大学, 2019.
    [37]
    卢永康, 陈窕圆, 庄贤勉, 等. 四君子汤调节大鼠肠道菌群改善心肌肥厚诱导心力衰竭的研究[J]. 现代中药研究与实践, 2020, 34(5): 29 – 33. doi: 10.13728/j.1673-6427.2020.05.006
    [38]
    唐华羽, 李玉芝, 李长德, 等. 四君子汤总多糖对小鼠肠道菌群及免疫功能的影响[J]. 陕西中医, 2016, 37(12): 1688 – 1691. doi: 10.3969/j.issn.1000-7369.2016.12.054
    [39]
    石 杨, 于洪宇. 参苓白术散治疗脾虚泄泻模型小鼠肠道局部免疫机制研究[J]. 免疫学杂志, 2018, 34(6): 519 – 523. doi: 10.13431/j.cnki.immunol.j.20180080
    [40]
    杨勋能. 参苓白术散对脓毒症患者肠道功能的影响[J]. 医学信息, 2019, 32(16): 146 – 148. doi: 10.3969/j.issn.1006-1959.2019.16.049
    [41]
    吴 利, 彭 玲, 陈 蓉. 葛根芩连汤临床应用及实验研究进展[J]. 河南中医, 2021, 41(4): 527 – 531. doi: 10.16367/j.issn.1003-5028.2021.04.0122
    [42]
    张文霞, 钟希文. 基于肠道菌群探讨葛根芩连汤对高脂饲料诱导的肥胖小鼠糖脂代谢的影响[J]. 时珍国医国药, 2020, 31(8): 1855 – 1858. doi: 10.3969/j.issn.1008-0805.2020.08.020
    [43]
    肖嫩群, 何云山, 张晨阳, 等. 葛根芩连汤对肠道湿热证泄泻小鼠肠道微生物的影响[J]. 中国微生态学杂志, 2020, 32(10): 1140 – 1144. doi: 10.13381/j.cnki.cjm.202010006
    [44]
    Liu CS, Liang X, Wei XH, et al. Gegen qinlian decoction treats diarrhea in piglets by modulating gut microbiota and short-chain fatty acids[J]. Front Microbiol, 2019, 10: 825. doi: 10.3389/fmicb.2019.00825
    [45]
    陈 阳, 陆 杰, 朱思敏, 等. 基于高通量测序技术研究葛根芩连汤及其配伍对急性肠炎大鼠肠道菌群多样性的影响[J]. 中国中药杂志, 2020, 45(6): 1406 – 1417. doi: 10.19540/j.cnki.cjcmm.20191112.401
    [46]
    李亚兰, 刘佳静, 马沛广, 等. 葛根芩连汤调控MMP-9/p38 MARK途径修复溃疡性结肠炎小鼠肠黏膜上皮屏障功能[J]. 中国实验方剂学杂志, 2021, 27(4): 8 – 15. doi: 10.13422/j.cnki.syfjx.20210436
    [47]
    朱金华, 周 军, 万红娇, 等. 黄连温胆汤对2型糖尿病模型大鼠细胞因子及TLR4、NF-κB变化的影响[J]. 中药药理与临床, 2021, 37(3): 6 – 11. doi: 10.13412/j.cnki.zyyl.2021.03.002
    [48]
    陈亚昕, 万红娇, 朱金华, 等. 黄连温胆汤对2型糖尿病模型鼠空腹血糖、INS及肠道菌群变化的影响[J]. 中药药理与临床, 2019, 35(3): 2 – 7. doi: 10.13412/j.cnki.zyyl.2019.03.001
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索
    Article views (57) PDF downloads(5) Cited by()
    Proportional views

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return