Diagnostic value of serum NPAR, MHR, CK-MB for severity of coronary artery lesions in patients with coronary heart disease

  AIM  To explore the diagnostic value of serum neutrophil percentage to albumin ratio (NPAR), neutrophil number to high-density lipoprotein cholesterol ratio (MHR) and creatine kinase-MB (CK-MB) for the severity of coronary artery lesions in patients with coronary heart disease.

  METHODS   The study subjects were 3937 patients with coronary heart disease who were continuously enrolled in the Department of Cardiology, Affiliated Hospital of Chengde Medical College from January 2016 to December 2018. The Gensini scores were calculated according to coronary angiography results and the patients with Gensini scores <14 were assigned to mild group (1339 cases) and those with Gensini score ≥14 were assigned to severe group (2598 cases). The patients’ clinical data were collected and CK-MB, NPAR and MHR were obtained. A binary logistic regression model was established and the predictive value of single index and combined indexes for the severity of coronary artery lesions was analyzed.

  RESULTS  The levels of serum NPAR, MHR and CK-MB in the severe coronary artery disease group were significantly higher than those in the mild group. The results of binary logistic regression showed that serum NPAR, MHR and CK-MB were the risk factors that affected the degree of coronary artery disease and could be used to assess the severity of coronary artery. P<0.05 was set as statistic significance and the prediction model was P=1/1+e^{−(−0.522+0.11×NPAR+0.54×MHR+0.06×CK-MB)}. The ROC curve showed that the area under the curve of serum NPAR, MHR and CK-MB were respectively 0.775, 0.618 and 0.615, and the predicted probability of combined detection of the three indexes was 0.80, which was significantly higher than that of one single index.

  CONCLUSION   Serum NPAR, MHR and CK-MB in patients with coronary heart disease are closely related to the severity of coronary artery lesions. The combined detection of the three indexes significantly enhances the predictive value for the severity of coronary artery lesions in patients with coronary heart disease.