AIM Compare the efficacy of antihypertensive drugs guided by gene testing results and doctor′s clinical experiences in patients with primary hypertension.
METHODS A total of 166 hypertension patients were enrolled from August 2019 to August 2020 in Tangdu Hospital.According to whether the antihypertensive drugs were selected by gene testing results, the study population was divided into the genetic guided group (57 cases) and the non-genetic guided group (109 cases).Basic data of patients, blood pressure before and after taking drugs, the number of drugs and adverse drug reactions were followed up and recorded.The differences of clinical efficacy between the two groups were analyzed by statistical methods.
RESULTS The control rate of blood pressure in the genetic guided group was significantly higher than that in the non-genetic guided group (P < 0.05), and the time to reach target blood pressure of the genetic guided group was less than that of the non-genetic guided group (P < 0.05). There was no statistical difference in adverse drug reactions.With grade 1 and 2 hypertension, the time to reach target blood pressure of the genetic guided group was less than that of the non-genetic guided group (P < 0.05).There was no statistical difference in adverse drug reactions.With grade 3 hypertension, systolic and diastolic blood pressure reduction values in the second, fourth and sixth week after taking drugs and control rate of the genetic guided group were higher than that of the non-genetic guided group.Also the time to reach target blood pressure of the genetic guided group was less than that of the non-genetic guided group, the difference was statistically significant (P < 0.05).There was no statistical difference in adverse drug reactions.
CONCLUSION Compared with doctor’s clinical experiences, medication under the guidance of genetic testing results is more effective and more advanced in controlling blood pressure.And there is no significant difference between the two groups in adverse drug reactions.
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