Effects of different doses of lidocaine on QTc interval in patients during anesthesia induction in laparoscopic hysteromyomectomy

  AIM  To evaluate the effect of different doses of lidocaine on QT interval (QTc) in patients during anesthesia induction in laparoscopic hysteromyomectomy.

  METHODS  Eighty patients with laparoscopic hysteromyomectomy were randomly divided into groups A (blank dose group), B (low dose group), C (medium dose group) and D (high dose group), with 20 cases in each group. After induction of anesthesia, groups B, C and D were intravenously infused with lidocaine (0.5 mg/kg, 1 mg/kg and 1.5 mg/kg respectively), while group A was intravenously infused with the same volume of saline. SBP, DBP, MAP, HR and ECG (QT interval) were recorded before anaesthesia induction (T₀), 2 min after induction drug injection (T₁) and 1, 3, 6 min after intubation (T_2-4).

  RESULTS  There was no obvious fluctuation in SBP, DBP, MAP and HR after intubation in D group and the level of QTc in each group was prolonged after anesthesia induction, but the T₂ time and T₃ time in group D after intubation were shorter than those in the other three groups. To some extent, the prolongation of QTc was inhibited.

  CONCLUSION  Intravenous infusion of 1.5 mg/kg lidocaine to patients in laparoscopic hysteromyomectomy after induction of anesthesia can keep the stability of hemodynamics and inhibit QTc prolongation during anesthesia induction.