Significance of plasma alarin and leptin changes in patients with acute coronary syndrome pre-and pro-coronary intervention

  AIM  To determine the changes in plasma levels of alarin and leptin before and after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS) and to explore the significance of their changes in ACS patients.

  METHODS  A total of 100 ACS patients who underwent PCI treatment in our hospital from August 2020 to October 2020 were collected and divided into AMI group (50 cases) and UA group (50 cases). At the same time, 50 patients with no coronary artery disease confirmed by coronary angiography wereselected as control group. According to the Gensini scores, the ACS patients were divided into three groups: A (Gensini scores>50 points), B (Gensini scores 25～50 points) and C (Gensini scores <25 points). Enzyme-linked immunosorbent assay was used to determine the plasma levels of alarin and leptin in all patients 5 minutes before and 48 hours after surgery. The differences in basic clinical data and laboratory indicators of each group were compared and the correlation between the alarin and leptin levels and the Gensini scores was analyzed.

  RESULTS  The levels of plasma alarin and leptin in AMI and UA groups were higher than those in control group at the same time point. The plasma alarin and leptin levels in AMI and UA groups after surgery were higher than those before the operation. The differences were statistically significant (All P<0.01). Preoperative and postoperative plasma alarin and leptin levels in ACS patients were positively correlated, and preoperative alarin and leptin levels as well as postoperative leptin level were positively correlated with Gensini scores (all P<0.05). The postoperative leptin levels in group A and group B was higher than those before operation, and the postoperative alarin level in group C was higher than that before operation. The difference was statistically significant (all P<0.05).

  CONCLUSION  Plasma alarin and leptin levels in ACS patients are elevated after PCI. In ACS patients, both can be used to assess the severity of inflammation and the possibility of in-stent restenosis and new coronary artery lesions after PCI.