Relationship between MHR and coronary artery stenosis in patients with CHD combined with EH

  AIM  To explore the relationship between the monocyte/high density lipoprotein cholesterol ratio (MHR) and the severity of coronary artery disease in patients with coronary heart disease and essential hypertension.

  METHODS  Four hundred and five patients with suspected coronary heart disease who underwent coronary angiography in our hospital were continuously selected. According to the results of the angiography and past medical history, the patients were divided into coronary heart disease combined with hypertension group (n=150), simple coronary heart disease group (n=95), simple hypertension group (n=80) and healthy control group (n=80). The degree of coronary artery disease in patients with coronary heart disease was evaluated by Gensini score. According to Gensini score, patients with coronary heart disease and hypertension were divided into three groups: A (Gensini score <15 points), B (Gensini score 15-30 points) and C (Gensini score> 30 points). General clinical data of each patient were collected and MHR was calculated.

  RESULTS  The MHR level in the coronary heart disease combined with hypertension group was higher than that in the other three groups (P<0.001). The MHR levels in the coronary heart disease combined with hypertension group and the simple coronary heart disease group were significantly positively correlated with Gensini score (r=0.234, P<0.01; r=0.266, P<0.01). Logistic regression analysis showed that elevated MHR level was an independent risk factor for the Gensini score in the coronary heart disease combined with hypertension group>30 points. The area under the ROC curve of MHR in the coronary heart disease combined with hypertension group > 30 points was 0.742 (95% CI: 0.658～0.827, P<0.01). The best cut point was 0.352, the corresponding sensitivity was 88.20% and the specificity was 60.00%. The best cut point for MHR to predict the Gensini score of coronary heart disease and hypertension was 0.352.

  CONCLUSION  MHR has a good predictive value for the severity of coronary artery disease in patients with coronary heart disease and hypertension.