Predictive value of Gal-3 and sST2 in evaluating PCI prognosis in patients with AMI

  AIM   To evaluate the prognostic value of serum galectin-3 (Gal-3) and soluble growth stimulating factor 2 (sST2) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI)

  METHODS   A total of 112 patients diagnosed with AMI and PCI in the Department of Cardiology, the First Affiliated Hospital of Zhengzhou University from August 2015 to October 2017 were selected. General clinical data of the patients were collected and the biochemical indicators of blood lipids were tested. After discharge, the patients were followed up for 3 years. According to whether the follow-up patients had major adverse cardiovascular events (MACE), they were divided into non-MACE group (n=34) and MACE group (n=78), and the clinical data of the two groups were compared. Logistic multivariate regression analysis was used to analyze the independent risk factors of MACE, and the receiver operating characteristic curve (ROC) was used to determine the best cut-off point of serum Gal-3 and sST2 expression.

  RESULTS   There was no significant difference in age, gender and other general information between the two groups. Compared with non-MACE group, the incidence of hypertension and hs-CRP in MACE group were significantly increased (P<0.05), the total cholesterol (TC), creatine kinase MB (CK-MB), sST2 and Gal-3 were significantly increased (P<0.01), and the left ventricular ejection fraction (LVEF) was significantly decreased (P<0.01). The multivariate logistic regression analysis showed that hypertension, CK-MB, hs-CRP, sST2, Gal-3 and LVEF were independent risk factors of MACE (P<0.05). Gal-3 predicts the area under the ROC curve of MACE to be 0.724, the cutoff point is 12.57 μg/ml, and its sensitivity is 68%, and its specificity is 96%; sST2 predicts the area under the ROC curve of MACE to be 0.765, and the cutoff point is 18.56 ng/ml, The sensitivity is 74%, and the specificity is 85%.

  CONCLUSION   Serum Gal-3 and sST2 are independent risk factors for MACE in AMI patients after PCI, and have a good predictive value for the outcome of AMI patients undergoing PCI.