The relationship between the expression of serum miR-499 and SOX6 and the prognosis of patients with acute myocardial infarction and its predictive value

  AIM  To explore the evaluation value of serum miR-499 and SOX6 expression on the prognosis of patients with acute myocardial infarction (AMI).

  METHODS  A total of 132 AMI patients diagnosed in the Department of Cardiology, Shijiazhuang People’s Hospital from February 2016 to October 2019 were selected. The general clinical data of the patients were collected, and the biochemical parameters of blood lipid were detected. The expression levels of miR-499 and Sox6 in the serum of the patients were detected by real-time quantitative PCR (RT-qPCR). Patients were divided into the MACE group (n=45) and the non-MACE group (n=87) according to the occurrence of major adverse cardiovascular events (MACE) during the follow-up period, and the clinical data of the two groups were compared. Logistic multivariate regression was used to analyze the independent risk factors for MACE, and receiver operating characteristic curve (ROC) was used to determine the optimal cut-off point of serum miR-499 and Sox6 expression levels.

  RESULTS  Compared with non-MACE group, the proportions of hypertension and diabetes in MACE group were significantly increased (P<0.05), the serum levels of TG, NT-proBNP, cTnI, hs-CRP and the relative expression of miR-499 were significantly increased (P<0.05), while the left ventricular ejection fraction (LVEF) fraction and the relative expression of serum Sox6 were significantly decreased (P<0.01). Multivariate Logistic regression analysis showed that hypertension, diabetes, hs-CRP and serum miR-499 expression were independent risk factors for the occurrence of MACE, while LVEF and serum SOX6 were protective factors for the occurrence of MACE. The area under the ROC curve of serum miR-499 for predicting MACE was 0.780 and the cut-off point was 0.86, with a sensitivity of 78.25% and specificity of 65.86%.The area under the ROC curve of serum SOX6 for predicting MACE was 0.721, the cutoff point was 0.75, the sensitivity was 78.87%, and the specificity was 62.58%.

  CONCLUSION  Serum miR-499 and SOX6 are independent risk factors for the occurrence of MACE in AMI patients, and have a good predictive value for the prognosis of AMI patients.