AIM To explore the risk factors of postoperative infection in patients with acute Stanford type A aortic dissection.
METHODS The clinical data of patients with acute Stanford type A aortic dissection who received surgical treatment in our hospital from June 2017 to December 2019 were analyzed retrospectively. According to whether infection occurred after surgery, the patients were divided into infection group (n = 69) and non-infection group (n = 35). The general conditions and perioperative data of the two groups were collected, and the risk factors of postoperative infection were analyzed using Logistic regression.
RESULTS This study included 104 patients with acute Stanford type A aortic dissection, 69 in the infection group and 35 in the non infection group. Compared with those in non-infection group, the temperature in infection group increased significantly before surgery (P<0.05), the cardiopulmonary bypass time, aortic cross clamp time and deep hypothermic circulatory arrest time were significantly longer (P<0.05), mechanical ventilation time, ICU stay time and total hospitalization time increased significantly (P<0.01), and the incidence of postoperative acute lung injury, acute kidney injury and systemic inflammatory response syndrome (SIRS) increased significantly (P<0.01). Multivariate logistic regression analysis showed that ICU stay time (OR = 1.503, 95% CI: 1.013～2.230, P<0.05) and SIRS (OR = 11.635, 95% CI: 1.515～89.336, P<0.05) were independent risk factors for postoperative infection in patients with acute Stanford type A aortic dissections.ROC curve analysis showed that the critical length of ICU stay was 7.5 days and the area under the curve was 0.865 (P<0.01).
CONCLUSION Postoperative infection will be significantly detrimental to the clinical prognosis of patients with acute Stanford type A aortic dissection. The length of stay in ICU >7.5 d and the postoperative SIRS were independent risk factors for postoperative infection.
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