AIM To explore the predictive value of serum periostin protein and hepatocyte growth factor (HGF) for cardiovascular events in patients with chronic heart failure.
METHODS We prospectively selected 108 patients with chronic heart failure admitted to our hospital from January 2018 to March 2019 for this study and another 50 healthy patients under physical examination severed as control group. ELISA was used to determine the serum levels of periostin protein and HGF at admission. According to the follow-up results, the patients were divided into group A (without cardiovascular events, 50 cases) and group B (with cardiovascular events, 58 cases). Logistic regression analysis was conducted to explore independent risk factors for cardiovascular events in patients with chronic heart failure. ROC curve was drawn to determine the predictive value.
RESULTS The serum levels of periostin protein and HGF in group B were significantly higher than those in group A (P<0.05). And the serum levels of Periostin protein and HGF in A、B groups were significantly higher than those in the control group (P<0.01); Multivariate results showed that age, BMI, hypertension, diabetes, periostin protein and HGF were independent risks of cardiovascular events in patients with chronic heart failure factors (P<0.05). Setting periodin=103.31 ng/L, HGF=901.72 (pg/ml) as the cut point, the predicted AUC was 0.915, the sensitivity was 92.98% and the specificity was 92.16.
CONCLUSION The elevated serum levels of periostin protein and hepatocyte growth factor can be used as reliable serum markers for cardiovascular events in patients with chronic heart failure.
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