AIM To evaluate the changes of left ventricular myocardial work in patients with breast cancer treated with different doses of anthracycline by non-invasive left ventricular pressure-strain ring (LVPSL).
METHODS Thirty-six postoperative patients with new breast cancer who were going to receive anthracycline chemotherapy and 30 healthy controls were selected. At least 3-5 cardiac cycles of left ventricular apical four-chamber, three-chamber and two-chamber were collected and stored, and the images were analyzed offline by workstation. Left ventricular end-diastolic diameter (LVDd), left ventricular end-systolic diameter (LVds), left ventricular ejection fraction (LVEF), left ventricular end-systolic volume (LVESV), left ventricular end-diastolic volume (LVEDV), global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE) were obtained.
RESULTS When the cumulative dose of anthracyclines reached 240mg/m² and 360mg/m², GLS and GWI were significantly lower than those before chemotherapy, while GWW was higher than that before chemotherapy. With the increase of the cumulative dose of anthracyclines, GLS and GWI decreased gradually, while GWW increased gradually. Correlation analysis showed that GLS was highly correlated with the cumulative dose of anthracycline (r = 0.653) （P<0.05）, while GWI and GWW were lowly correlated with the cumulative dose of anthracycline (r =−0.485, r = 0.308) （P<0.05）.
CONCLUSION The global work index and global useless work of LVPSL can be used to evaluate the mild left ventricular myocardial dysfunction caused by anthracycline therapy in breast cancer patients and it is dose-dependent.
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