AIM To analyze the correlation of the peripheral blood microRNA-106b-5p(miR-106b-5p) in patients with acute ST segment elevation myocardial infarction (STEMI) with ventricular remodeling (VR) and major adverse cardiac events (MACE) after infarction.
METHODS 90 STEMI patients from January 2018 to February 2020 were selected as the STEMI group, as the same time, 90 cases of stable coronary heart disease (SCAD) were confirmed by clinical and coronary angiography as the SCAD group. The real-time quantitative reverse transcription polymerase chain reaction (qrt-PCR) was used to detect the peripheral blood mir-106b-5p in 2 groups as the admission, 2 days after treatment and 6 months after discharge. According to the results of color doppler echocardiography of the STEMI group after surgery and 6 months after discharge, the VR of the STEMI group was judged.Take STEMI diagnostic threshold as the boundary, to analyze the relationship between mir-106b-5p and VR in the STEMI group.Kaplan-Meier survival curve was used to analyze the major adverse cardiac events (MACE) of patients with different miR-106b-5p levels in STEMI group at 12 months after discharge.
RESULTS In the high expression subgroup (miR-106b-5p ≥ 0.41, 58 patients), VR occurred in 1 case (1.72%) 6 months after discharge, which was significantly lower than that in the low expression subgroup (miR-106b-5p <0.41, 32 cases)(15.60%). (χ2=4.564, P<0.05). MACE (1 case myocardial infarction and 1 case stroke) occurred in 2 cases (3.45%) of the high expression subgroup during 12 months’ follow-up, which was lower than 5 cases (15.63%) of the low expression group (3 cases myocardial infarction and 2 cases stroke) (Log-rank χ2=4.725, P<0.05). The level of miRNA-106-5p in peripheral blood was negatively correlated with LVEDd at 6 months after discharge (r =−0.437, P<0.05), positively correlated with LVEF (r = 0.414, P<0.05).
CONCLUSION There is a correlation between miR-106b-5p in peripheral blood and VR and MACE after myocardial infarction.
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