Expression levels of CXCR3, its ligand MIG and IP-10 and the degree of coronary artery disease in patients with coronary heart disease

  AIM  Investigate the relationship between the expression levels of CXCR3, its ligand MIG and IP-10 and the degree of coronary artery disease in patients with coronary heart disease.

  METHODS  A total of 200 patients with coronary atherosclerotic heart disease who were hospitalized in the department of cardiology of our hospital from Jun 2017 to July 2019 were selected, and all of them underwent coronary angiography to determine whether they were coronary heart disease(CHD). The expression levels of CXCR3, MIG and IP-10 in serum of patients were detected by ELISA, and the expression levels of CXCR3, MIG and IP-10 in the two groups were compared, and the expression levels of CXCR3, MIG and IP-10 in each subgroup of CHD were compared. The levels of T cell subsets, Th1, Th2 and Th1/Th2 in peripheral blood of CHD group and non-CHD group were compared. The correlation between CHD, CXCR3 and its ligands, MIG, IP-10, were analyzed.

  RESULTS  Of the 200 patients, 78 were CHD patients and 122 were non-CHD patients. CXCR3, MIG and IP-10 expression levels of CHD patients were significantly higher in the CHD group than in the non-CHD group, with statistically significant differences (P<0.01). Among the 78 patients with CHD, 36 patients with one lesion, 23 patients with two lesions, and 19 patients with multiple lesions. After ANOVA, there were statistically significant differences in CXCR3, MIG and IP-10 expression levels among each CHD subgroup (P<0.01). The higher the degree of coronary artery lesions, the higher the expression levels of CXCR3 and its ligands MIG and IP-10. CD3+, CD4+, CD4+/CD8+ levels in the CHD group were significantly lower than those in the control group, with statistically significant differences (P<0.01). Th1 and Th1/Th2 levels in the CHD group were significantly higher than those in the non-CHD group, and Th2 levels were significantly lower than those in the non-CHD group, with statistically significant differences (P<0.01). According to Logistic regression analysis, the expression levels of CXCR3 and its ligands, MIG and IP-10 have a significant effect on CHD. (P<0.01).

  CONCLUSION  The expression levels of CXCR3 and its ligands MIG and IP-10 can be used as serological inflammatory cytokines of CHD which can reflect the severity of CHD, and deserve further clinical research.