AIM To evaluate the effect of oral anticoagulants (OACs) on the long-term adverse prognosis in patients with atrial fibrillation and coronary artery disease at high risk of thrombosis after percutaneous coronary intervention (AF-PCI).
METHODS A retrospective study was performed on 108 patients with AF-PCI at high risk of thrombo hospitalized in Beijing Tonren hospital from January 2013 to January 2019. All patients were divided into with OACs group (n=45) and in the other group (n=63). We followed up and compared two groups of systemic thromboembolic events, major adverse cardiovascular and cerebrovasluar events (MACCE) including systemic thromboembolism, cardiovascular death, recurrence of acute myocardial infarction, treatment for stent thrombosis and revascularization and serious bleeding events to evaluate the effect of OACs on long-term adverse prognosis in patients with AF-PCI at high risk of thrombo .
RESULTS In total, there were 15 systemic thromboembolism events that happened during the follow-up period. Of the total cases, three cases (7%) of thromboembolism events in with OACs groups was lesser than 12 cases (19%) in the other group. The statistical difference between them was P<0.05. Twenty-six cases of MACCE were observed, 6 cases (13%) and 20 cases (44%), respectively, showed a statistically significant difference P<0.05. There were 11 cases (24%) of bleeding events in OACs groups and 11 cases (18%) in the other group, both of which were minor bleeding events, without significant difference.
CONCLUSION The use of OACs is obviously insufficient in patients with AF-PCI and high risk of thromboembolism, however, OACs effectively reduce the risk of without increasing bleeding.
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