AIM To investigate the correlation between serum glutamyl transferase and soluble intercellular adhesion molecule-1 and the absence of myocardial regurgitation after PCI in acute myocardial infarction.
METHODS Included in the study were 335 patients with acute ST segment elevation myocardial infarction who were treated by PCI in our hospital From January 2017 to December 2019. Their blood samples were collected and serum GGT and sICAM-1 levels were determined. According to the myocardial infarction thrombolysis test blood flow classification during PCI, the patients were divided into myocardial reperfusion group and non-reflow group, and the serum detection index and cardiac function index of the two groups were compared.
RESULTS Among the 335 patients with STEMI, there were 47 cases in myocardial no-reflow group and 288 cases in myocardial reperfusion group. The levels of diabetes, troponin I and brain natriuretic peptide precursor between the two groups were significantly different (P<0.05, P<0.01). The length of lesions and the time from onset to vascular recanalization in reperfusion group were significantly different from those in non-reflow group (P < 0.01). Serum GGT and serum sICAM-1 levels were significantly higher in non-reflow group immediately after PCI and at 48h after reperfusion (P < 0.05). Serum GGT and serum sICAM-1 levels immediately and at 48h after PCI in non-reflow group were significantly higher than those in non-reflow group (P < 0.05). Serum GGT and serum sICAM-1 levels at 48h after PCI in non-reflow group were significantly higher than those immediately after PCI (P < 0.05). Multivariate logistic analysis showed that the time from onset to recanalization, GGT and sICAM-1 were independent risk factors for myocardial no-reflow (P < 0.05).
CONCLUSION Serum GGT and sICAM-1 are related to myocardial no-reflow after acute myocardial infarction and their elevated levels may be risk factors for myocardial no-reflow.
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