Functions and clinical research progress of nebulin-related-anchoring protein

Nebulin-related-anchoring protein (NRAP) is a multi-domain skeletal protein that is specifically expressed at the myocardial intercalated disc and the tendon junction of skeletal muscle. It plays an important role in the assembly process of myofibrils and participates in anchoring the terminal actin filaments of myofibrils to the cell membrane to transfer tension from myofibrils to extracellular matrix. Up to now, clinical research reports on NRAP are mostly found in muscular lesions, but in recent years, there are new reports of NRAP gene mutation and dilated cardiomyopathy. This article reviews the structure, biological functions and research progress of NRAP.