Diagnostic value of lipoprotein-associated phospholipase A₂ for silent myocardial ischemia

  AIM  To investigate the diagnostic value of detecting lipoprotein-associated phospholipase A₂ (Lp-PLA₂) for silent myocardial ischemia (SMI).

  METHODS  According to coronary angiography results, 68 SMI patients consisted of study group and 104 subjects with normal coronary served as control group. The SMI group was subdivided into three groups: single-vessel lesion group, two-vessels lesion group and three-vessels lesion group. The activity levels and concentrations of Lp-PLA₂ were detected in both groups and the results were analyzed statistically.

  RESULTS  In SMI group, the concentrations of Lp-PLA₂ were significantly higher compared with those in the control group (P<0.5), but the activity level difference was not statistically significant. The mass concentrations of Lp-PLA₂ in two-vessels lesion group were significantly different from those in three-vessels lesion group (P<0.05), but they were not significantly different from those in single-vessel lesion group.

  CONCLUSION  Detecting Lp-PLA₂ has great significance in diagnosis and severity evaluation of SMI.