Association between CYP1A2 genetic polymorphisms and coronary artery disease in Uygur population in Xinjiang, China

  AIM  to investigate the correlation between CYP1A2 polymorphism and coronary heart disease in uygur and han populations in Xinjiang province.

  METHODS  The present investigaiton used two independent case-control studies: the han population (389 CHD patients and 411 controls) and the uygur population (293 CHD patients and 408 controls). Single nucleotide polymorphisms (rs2069522, rs2472304) of CYP1A2 were genotyped by real-time PCR.

  RESULTS  Only in the han population, the distribution of SNP1 (rs2069522) genotype was statistically significant between the CHD group and the control group (p < 0.05). There was no significant difference in the uygur population.The genotype frequency of SNP1 (rs2069522) dominant model (CC vs CT + TT) in the case group was significantly higher than that in the control group. Logistic regression analysis after adjusting for confounders showed that the risk of coronary heart disease of CC genotype in xinjiang han population was significantly higher than that of CT + TT genotype (overall: OR = 1.982, 95%CI: 1.174 ~ 3.236, P < 0.01). Male: OR = 2.671, 95%CI: 1.548 ~ 4.314, P < 0.01).

  CONCLUSION  This locus of rs2069522 in CYP1A2 gene of xinjiang han population is associated with coronary heart disease. CC genotype may be a risk factor for CHD in han Chinese rather than uygur.